The lift-off was broadcast live on Indian television networks to an audience of hundreds of millions - ISRO
India has successfully launched its second lunar mission a week after it halted the scheduled blast-off due to a technical snag.
Chandrayaan-2 was launched at 14:43 local time (09:13 GMT) on Monday from the Sriharikota space station.
India's space chief said his agency had "bounced back with flying colours" after the aborted first attempt.
India hopes the $150m (£120m) mission will be the first to land on the Moon's south pole, BBC reports.
The lift-off was broadcast live on TV and the space agency's official social media accounts.
There was applause in the Indian Space Research Organisation (Isro) control room minutes after the launch, as the rocket took off towards the outer atmosphere.
It is the most complex mission ever attempted by the agency.
"It is the beginning of a historical journey of India towards the moon," said Isro chief K Sivan in a speech after the launch.
He thanked and congratulated all those who had worked on the mission: "It is my duty to salute all the people who have done the work."
The countdown on 15 July was stopped 56 minutes before launch after a "technical snag was observed in [the] launch vehicle system", according to Isro. Indian media have reported that a leak from a helium gas bottle in the cryogenic engine of the rocket was to blame.
The fuel from the rocket was drained and the scientists resolved the glitch.
"It was a simple to fix [but it was] a serious problem that could have resulted in total failure," said a source at Isro.
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