Fires are still burning after a UPS cargo plane crashed during takeoff at Louisville International Airport in Kentucky.
Three deaths have been confirmed so far but local officials expect that number to grow, reports BBC.
At least 11 people are being treated for injuries and others are missing - people living nearby have been told to seek shelter.
The aircraft was carrying around 38,000 gallons of fuel when it exploded, with flames engulfing nearby businesses.
UPS says three crew members were on board - all are still unaccounted for.
Flight 2976, which was bound for Hawaii, crashed at around 17:15 local time, the US Federal Aviation Administration says.
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